Metabolism: Oxycodone hydrochloride is extensively metabolized to noroxycodone, oxymorphone, and their glucuronides. The main circulating metabolite is noroxycodone with an AUC ratio of 0.The concomitant use of OXYCONTIN and CYP3A4 inducers can lower the plasma concentration of oxycodone [see Medical PHARMACOLOGY], resulting in decreased efficacy o